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Head to head

Logitech Signature M650 vs Logitech Signature Comfort Plus M850 L: which one is right for you

Head-to-head comparison of Logitech Signature M650 and Logitech Signature Comfort Plus M850 L with official manufacturer specs: what really sets them apart, where each one wins and which fits your body and your working hours better.

Logitech Signature M650
Logitech 118 mm
72 Editor's score
VS
Logitech Signature Comfort Plus M850 L
Logitech 121.3 mm
48 Editor's score
The verdict
Logitech Signature M650 wins on 2 of 4 objective criteria.
Logitech Signature M650Logitech Signature Comfort Plus M850 L
Hand sizesS / M / LM / L
Vertical angle
Left-hand friendlyYesNo
ConnectionWirelessWireless
The evidence, category by category
Logitech Signature M650Logitech Signature Comfort Plus M850 L
Wrist neutrality
55
55
Versatility
100
60
Size coverage
100
60
Value for money
33
19

Scores 0-100 derived from the manufacturer's specs with the same method for both — published method.

When should you choose Logitech Signature M650?

Anyone who wants comfort without changing the classic mouse grip.

When should you choose Logitech Signature Comfort Plus M850 L?

Large hands that want the classic mouse shape with extra palm support and years of battery life.

Frequently asked questions

Is it worth paying the difference?

It depends on whether the advantages the pricier one brings are on your list of needs. Our table marks with ✓ which one wins each objective criterion; if the criteria it wins don't affect you, don't pay for them.

How do I know which one fits my body?

No generic comparison answers it: it depends on your height, weight, hours a day and hand size. Each category's filter crosses your measurements with the specs and gives you a fit % for each one.

And which one fits YOU? Put your measurements in the category filter and you will see them sorted by your real fit %.

Where to go next